Clinical Trials

Access to Novel Treatments and Promising New Therapies


Committed to Innovation

With our affiliation with Cancer Partners of Nebraska, we can offer a breadth of access to clinical trials, thanks to their membership in two major National Cancer Institute (NCI) research networks: Alliance is an affiliate of MD Anderson Cancer Center and ECOG-ACRIN Cancer Research Group.

  • Patient recruitment and enrollment in promising clinical trials are essential to their work.
  • Cancer Partners of Nebraska is the first and only community oncology practice in Nebraska to become a member institution of the NCI clinical trials network.
  • The expanded clinical trials offered bring academic-level treatment options to the local community.
  • They have access to over 300 new and innovative clinical trials for patients.

Clinical Trials

See What Clinical Trials Are Open Right Now

Most clinical trials at Cancer Partners are interventional studies, meaning patients are assigned to a treatment or other intervention and their outcomes are measured. See the full list below sorted by type of cancer. If you wish to discuss a specific trial, please discuss it with your physician or contact Cancer Partners of Nebraska Research Department at (402) 327-7363.

Breast Cancer

EA1181 – Her-2 positive Stage II-IIIa Breast Cancer

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy – (some cohorts closed, check with Research Department)

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NRG-BR007/DEBRA - Stage I, s/p lumpectomy


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NRG-BR008 - HER2+, Low risk Breast Cancer

A Phase III Randomized Trial of Radiotherapy Optimization for Low-Risk HER2-Positive Breast Cancer (HERO*) *Her2 Radiation Optimization (HERO)

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Central Nervous System Tumors (Brain and Spinal Cord) Cancer

A071702 - WHO Grade IV GBM (Glioblastoma)

A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioblastoma With Elevated Mutational Burden

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Hematologic Cancer

CONNECT MDS/AML Myeloid Disorders

The Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) Disease Registry

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S1918 (DLBCL age >75) Diffuse Large B Cell Lymphoma

A Phase II/III Randomized Study of R-MiniCHOP with or Without CC-486 (Oral Azacitidine) in Participants Age 75 Years or Older with Newly Diagnosed Diffuse Large B Cell Lymphoma, Grade IIIB Follicular Lymphoma, Transformed Lymphoma, and High-Grade B-Cell Lymphomas with MYC AND BCL2 and/or BCL6 Rearrangements

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Connect Lymphoma

Connect® Lymphoma Disease Registry: A US-Based Prospective Observational Cohort Study

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S1925 Asymptomatic High-Risk CLL/SLL

Randomized, Phase III Study of Early Intervention with Venetoclax and Obinutuzumab Versus Delayed therapy with Venetoclax and Obinutzumab in Newly Diagnosed Asymptomatic High-Risk Patient with DLL/CLL: EVOLVE CLL/SLL Study.

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S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration (DRAMMATIC)

(Temp Closed) Phase III Study of Daratumumab/rHuPH20 (NSC-810307) + Lenalidomide or Lenalidomide as post-autologous stem cell transplant maintenance therapy in patients with MM using minimal residual disease to direct therapy duration (DRAMMATIC STUDY).

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Gastrointestinal Cancer

A221805 – Stage II-III Colon Cancer Receiving Oxaliplatin (Early Stage Colon Cancer)

(Temp Closed) Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Phase II to Phase III Study

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EA2186 GIANT - Metastatic Pancreatic

1ST line Metastatic Pancreatic – A Randomized Phase II Study of Gemcitabine and Nab-Paclitaxel Compared with 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan in Older Patients with Treatment Naïve Metastatic Pancreatic Cancer (GIANT)

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KRYSTAL-10 Advanced Colorectal Cancer with IV KRAS G12C Mutation

Phase 3 Study of MRTX849 in Combination with Cetuximab Versus Chemotherapy in Patients with Advanced Colorectal Cancer with KRAS G12C Mutation with Disease Progression On or After Standard First-Line Therapy

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Thoracic Cancer

Unresectable Stage III or Metastatic (M1a) NSCLC - EF-36/Keynote B36

OPENING SOON – Effect of Tumor Treating Fields (TTFields) (150 kHz) Concurrent With Pembrolizumab for Treatment of Advanced Non-small Cell Lung Cancer (NSCLC) (KEYNOTE B36)

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D9103C00001 – (PACIFIC-4) Non-Small Cell Lung Cancer (NSCLC) Patients

Durvalumab vs Placebo With Stereotactic Body Radiation Therapy in Early Stage Unresected Non-Small Cell Lung Cancer (NSCLC) Patients / Osimertinib Following SBRT in Patients With Early Stage Unresected NSCLC Harboring an EGFR Mutation

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D910LC00001 (MeRmaiD-1) Operable Non-Small Cell Lung Cancer

(CLOSED) Stage II-III Resected NSCLC – A Phase III, Randomized, Multicenter, Double-blind, Placebo-controlled Study to Determine the Efficacy of Adjuvant Durvalumab in Combination with Platinum-based Chemotherapy in Completely Resected Stage II-III NSCLC

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A151216 - Resected Non-Small Cell Lung Cancer

Stage II-III Resected NSCLC – Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)

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EA5182 - Stage IV EGFR Mutated NSCLC 1st line treatment (Metastatic Non-Small Cell lung cancer, EGRF Mutated)

Randomized Phase III Study of Combination AZD9291 (Osimertinib) and Bevacizumab Versus AZD9291 (Osimertinib) Alone as First-Line Treatment for Patients With Metastatic EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC)

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OPENING SOON – Durvalumab and Carboplatin Versus Pembrolizumab in Combination With Platinum-based Chemotherapy for the First-line Treatment of Patients With Locally Advanced or Metastatic NSCLC Without Actionable Genomic Alterations (D926NC00001; AVANZAR)

A081801 - Stage II-III (Resected Non-Small Cell Lung Cancer)

Integration of Immunotherapy into Adjuvant Therapy for Resected NSCLC: ALCHEMIST CHEMO-IO (ACCIO)

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E4512 - Stage II-III ALK + Resected Non-Small Cell Lung Cancer

A Randomized Phase III Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Observation for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein

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EA5181 - Unresectable Stage III Non-Small Cell Lung Cancer

Randomized Phase III Trial of MEDI4736 (durvalumab) as Concurrent and Consolidative Therapy of Consolidative Therapy Alone for Unresectable Stage 3 NSCLC

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Genitourinary Cancer

A031704 (PDIGREE) - Treatment Naïve Metastatic Renal Cell Carcinoma

PD-Inhibitor (Nivolumab) and Ipilimumab Followed by Nivolumab Vs. VEGF TKI Cabozantinib with Nivolumab: A Phase III Trial in Metastatic Untreated Renal Cell Cancer [PDIGREE]

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NRG-GU008 (INNOVATE) - Prostate Cancer, Treatment after Prostatectomy

Randomized Phase III Trial Incorporating Abiraterone Acetate with Prednisone and Apalutamide and Advanced Imaging into Salvage Treatment for Patients with Node-Positive Prostate Cancer after Radical Prostatectomy

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HER2+ Urothelial Carcinoma

An Open-label, Randomized, Controlled Phase 3 Study of Disitamab Vedotin in Combination with Pembrolizumab Versus Chemotherapy in Subjects with Previously Untreated Locally Advanced or Metastatic Urothelial Carcinoma that Expresses HER2 (IHC 1+ and Greater)


MK6482-011 - Progressive Metastatic Renal Cell Carcinoma

Phase 3 Study of MK-6482 in Combination With Lenvatinib Versus Cabozantinib for Second-line Treatment of mRCC

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A Randomized Phase II trial of triplet therapy (a PD-L1 inhibitor durvalumab in combination with Olaparib and Cediranib) compared to Olaparib and Cediranib or Durvalumab and Cediranib or standard of care chemotherapy in women with Platinum-resistant recurrent epithelial ovarian cancer, primary peritoneal or fallopian cancer who have received prior Bevacizumab

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Solid Tumor

MAPK Pathway-altered Malignancies

ULI-EAP-100 – Expanded Access To Ulixertinib (Bvd-523) In Patients With Advanced Mapk Pathway-Altered Malignancies

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MK7339-002 (LYNK-002) Previously Treated, HRR/HRD +

A Phase 2 Study of Olaparib Monotherapy in Participants with Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer

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CASE - Cutaneous Squamous Cell Carcinoma

Cemiplimab Survivorship Epidemiology Study

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S2000 - Metastatic Melanoma

A Randomized Phase II Trial of Encorafenib + Binimetinib + Nivolumab vs Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma with Brain Metastases

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Caris Biorepository (Matched Tumor)

Solid Tumor Matched Tissue and Blood Collection

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MT Group (MTG-022)

The list of available biomarker studies is always changing. Please contact Cancer Partners Research Department for the most current list.

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